Paracetamol, Pheniramine Maleate , Phenylephrine HCl & Ascorbic acid Sachets

2. Weighing and Mixing:

• The required quantities of Paracetamol, Pheniramine Maleate, Phenylephrine HCl, and Ascorbic Acid are accurately weighed according to the formulation.
• These ingredients are then thoroughly mixed in a high-capacity blender under controlled conditions to achieve homogeneity.

3. Granulation:

• The homogeneous mixture is granulated using a wet process to improve flow properties and compressibility.
• Granules are formed by adding a suitable binder solution and passing the damp mass through a granulator.
• The granules are dried to reduce moisture content and enhance stability.

4. Compression:

• The dried granules are compressed into individual sachets using high-speed rotary tablet presses equipped with punches of the appropriate size.
• Compression parameters such as compression force, tablet thickness, and hardness are closely monitored to ensure uniformity.

5. Quality Control Checks:

• Throughout the manufacturing process, in-process quality control checks are conducted at critical stages to verify compliance with specifications.
• Samples are collected and analyzed for content uniformity, dissolution rate, and physical characteristics.

6. Sachet Filling:

• The compressed sachets are transferred to a dedicated filling line equipped with automatic sachet filling machines.
• Each sachet is accurately filled with the appropriate dose of the oral suspension formulation.

7. Sealing and Packaging:

• Filled sachets are hermetically sealed using heat sealing technology to prevent contamination and preserve product integrity.
• Sealed sachets are then packed into primary packaging materials such as aluminum foil or laminate films, ensuring protection from moisture and light.
• Finally, the packaged sachets are labeled with product information, including dosage instructions, batch number, and expiry date.

8. Finished Product Testing:

• Random samples from each batch undergo comprehensive testing in the quality control laboratory to verify compliance with specifications.
• Final testing includes assays for active ingredients, microbiological analysis, dissolution testing, and stability studies.

9. Storage and Distribution:

• Finished products are stored in a controlled environment with appropriate temperature and humidity conditions to maintain stability.
• Before distribution, products are inspected to confirm packaging integrity and compliance with labeling requirements.
• Products are then dispatched to wholesalers, distributors, and, ultimately, pharmacies for distribution to end consumers.